Chicken baked in a rich cream of mushroom sauce is an easy, family-friendly dinner that's ready with minimal prep. This protein-packed chicken dish pairs well with rice or egg noodles.
Preheat your oven to 375°F. Lightly grease a 9x13-inch baking dish for even heat distribution and easy cleanup.
Slice the fresh mushrooms. In a skillet over medium heat, melt the unsalted butter and sauté mushrooms just until softened, about 4 minutes.
Arrange the chicken breasts in a single layer in the prepared baking dish. Season both sides with salt, black pepper, garlic powder, and onion powder for balanced flavor.
Spread the sautéed mushrooms over the chicken, then pour the cream of mushroom soup evenly on top, making sure all chicken pieces are well coated.
Cover the dish with foil and bake for 25 minutes. Remove foil and bake an additional 20 minutes, or until chicken reaches an internal temperature of 165°F and sauce bubbles gently. Rest for 5 minutes before serving.