Southern fried catfish with a crispy cornmeal crust is a high protein tradition served with hush puppies and coleslaw. This family classic delivers a satisfying crunch in every bite.
Rinse and pat dry the catfish fillets; season lightly with kosher salt on both sides.
Pour buttermilk into a shallow dish and soak the catfish fillets for at least 30 minutes, turning halfway.
In a large bowl, combine cornmeal, flour, remaining salt, black pepper, paprika, garlic powder, and cayenne pepper.
Heat vegetable oil in a large cast iron skillet to 350°F (medium-high); use a thermometer for precise control.
Dredge each fillet in the cornmeal mixture, pressing firmly to coat; gently shake off excess and carefully lay into hot oil.
Fry the catfish without crowding the pan, 4–5 minutes per side, turning only once, until the crust is deep golden brown and crisp.
Transfer fillets to a wire rack or paper towels to drain. Let rest 2 minutes before serving for best texture.