On Wegovy or Mounjaro, eating out often means exposure to fried foods and heavy sauces — making home-cooked fish tacos a GLP-1 essential. Tilapia is among the leanest white fish with virtually no fat, delivering pure protein that supports muscle preservation during GLP-1 weight loss. Avoid fried fish tacos in flour tortillas with sour cream and shredded cheese that add excess fat and refined carbs. Lettuce wraps eliminate the refined carb issue entirely while adding satisfying crunch.
Season tilapia with cumin, paprika, garlic powder, salt, and olive oil.
Heat a non-stick pan over medium-high heat.
Cook tilapia 3–4 minutes per side until opaque and flakes easily.
Break into bite-sized pieces.
Mix diced mango, red onion, cilantro, and lime juice in a bowl for mango salsa.
Wash and dry butter lettuce leaves.
Fill each lettuce leaf with tilapia pieces and mango salsa.
Squeeze extra lime juice on top and serve immediately.