Golden, crispy Southern fried chicken with a perfectly seasoned buttermilk crust is America's most beloved chicken dish. This high protein family classic delivers juicy, flavorful meat with an irresistible crunch.
Combine buttermilk with 1 teaspoon kosher salt and 0.5 teaspoon black pepper in a large bowl. Add chicken pieces, ensuring each is fully submerged. Cover and refrigerate for at least 2 hours or overnight for juiciest results.
Remove chicken from the buttermilk, letting excess drip off. In a large baking dish, mix flour, remaining salt, pepper, paprika, garlic powder, onion powder, and cayenne until evenly blended.
Dredge each chicken piece in the seasoned flour, pressing firmly so the coating adheres well on all sides. Place coated chicken on a wire rack and let it stand for 10–15 minutes to help the crust set.
Fill a deep cast-iron skillet with about 1 inch (using 3 cups) of vegetable oil. Heat oil to 340–350°F over medium-high heat. Carefully add chicken in batches without crowding the pan—oil temperature must stay at 340–350°F throughout frying.
Fry chicken 12–16 minutes, turning once, until deep golden brown and crispy, and an instant-read thermometer registers 165°F in the thickest part. Remove to a clean wire rack to drain briefly before serving. Enjoy hot for maximum crunch.